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EnBIO's third offering is a drug eluting surface for metallic medical implants. Work on this is ongoing. However, the initial draft specification has three main components.
- Possibility of eluting a broad range of drugs. Initial focus is on antibiotics
- Applicable to the full range of metallic implant surfaces (Ti, NiTi, CoCr and various Stainless Steels)
- Customizable elution profile,
- few hours (e.g. as a burst of antibiotics for infection control in the immediate time after the surgery)
- few days (e.g. 10 days for general infection control)
- few months (e.g. 2 to 3 months elution of sirolimus for drug eluting stents)
- The drug cannot elute at concentrations less than the Minimum Effective Concentration (MEC) in the case of antibiotics
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Advantages
- Stepping stone technology (HA > Antimicrobial > Drug Eluting).
- Drugs delivery/attachment is possible and it remains fully potent post-delivery. Many active drugs cannot be applied using other methods as they are temperature sensitive and will not withstand the high temperature and highly complex, multi-step processing environments.
- Mixed drugs possible - Enhances primary function of device or add secondary function if desired.
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